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biosensingforlife

INNOVATIVE APPROACHES FOR RAPID FENTANYL DETECTION IN TRAFFICKED CARGO

Project Goal

  • Development of a non-contact, and highly sensitive vapor-based sensor for accurate and selective detection of illicit fentanyl and related substances.
  • Designing and realization of a robotic platform equipped with the novel sensor towards rapid and on-site detection of the opioid.

Scientific Background

  • Fentanyl and its analogs are synthetic opioids that can be easily concealed, transported in small quantities, and mixed with other substances, making it challenging to locate during trafficking intervention.
  • Limitations of Existing Techniques:
    • Immunoassays: These can be prone to false positives or require skilled personnel and laboratory analysis, limiting their on-site utility.
    • Mass Spectroscopy/ IMS: Though accurate, these systems are often bulky, expensive, and require specialized operators, making them unsuitable for rapid field deployment.
    • Electrochemical Methods: While potentially portable, their sensitivity and selectivity for complex mixtures might be limited for on-site fentanyl screening.

Key Innovations

  • Development of a novel chemiresistive sensor to achieve a lower detection limit of 100 ppb of fentanyl detection, improving sensitivity and selectivity.
  • Immobilization of detection media on a solid-state hydrogel substrate for improved portability and ease of use, addressing issues of liquid media detection methods.
  • Assembly of a colorimetric sensor array for all opioid drugs in a panel for multiplexing, enabling the detection of a wide range of drugs simultaneously.
  • Mounting a sensor array on a robotic hand for portable, non-contact, vapor-phase detection, facilitating dynamic monitoring of absorption wavelength changes.
  • Utilization of electronic nose (e-nose) technology to detect fentanyl based on volatile organic compounds (VOCs), offering a non-contact detection method.
  • Development of a fully automated robotic arm coupled with a spectrophotometer for remote sensing and detection of fentanyl, enhancing efficiency and accuracy in detection processes.